Iridium-Catalyzed Single-Step <i>N</i>‑Substituted Lactam Synthesis from Lactones and Amines

2015-04-17T00:00:00Z (GMT) by Kicheol Kim Soon Hyeok Hong
Catalytic lactam synthesis was achieved directly from lactones and amines using an Ir catalyst. Three sequential transformationsaminolysis of lactone, <i>N</i>-alkylation of amine with hydroxyamide, and intramolecular transamidation of aminoamideafforded the corresponding <i>N</i>-substituted lactams.