Iridium-Catalyzed Single-Step N‑Substituted Lactam Synthesis from Lactones and Amines
2015-04-17T00:00:00Z (GMT) by
Catalytic lactam synthesis was achieved directly from lactones and amines using an Ir catalyst. Three sequential transformationsaminolysis of lactone, N-alkylation of amine with hydroxyamide, and intramolecular transamidation of aminoamideafforded the corresponding N-substituted lactams.
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