Iridium-Catalyzed Single-Step N‑Substituted Lactam Synthesis from Lactones and Amines

Catalytic lactam synthesis was achieved directly from lactones and amines using an Ir catalyst. Three sequential transformationsaminolysis of lactone, N-alkylation of amine with hydroxyamide, and intramolecular transamidation of aminoamideafforded the corresponding N-substituted lactams.