Iridium-Catalyzed Single-Step N‑Substituted Lactam Synthesis from Lactones and Amines

2015-04-17T00:00:00Z (GMT) by Kicheol Kim Soon Hyeok Hong
Catalytic lactam synthesis was achieved directly from lactones and amines using an Ir catalyst. Three sequential transformationsaminolysis of lactone, N-alkylation of amine with hydroxyamide, and intramolecular transamidation of aminoamideafforded the corresponding N-substituted lactams.