Iodide-Catalyzed Synthesis of Secondary Thiocarbamates
from Isocyanides and Thiosulfonates

Mampuys, Pieter; Zhu, Yanping; Sergeyev, Sergey; Ruijter, Eelco; V. A. Orru, Romano; Doorslaer, Sabine Van; U. W. Maes, Bert

doi:10.1021/acs.orglett.6b01023.s001

ol6b01023_si_001.pdf (11.43 MB)

Iodide-Catalyzed Synthesis of Secondary Thiocarbamates from Isocyanides and Thiosulfonates

journal contribution

posted on 2016-06-08, 17:04 authored by Pieter Mampuys, Yanping Zhu, Sergey Sergeyev, Eelco Ruijter, Romano V. A. Orru, Sabine Van Doorslaer, Bert U. W. Maes

A new method for the synthesis of secondary thiocarbamates from readily available isocyanides and thiosulfonates with broad functional group tolerance is reported. The reaction proceeds under mild reaction conditions in isopropanol and is catalyzed by inexpensive sodium iodide.