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Investigation of Antibacterial 1,8-Cineole-Derived Thin Films Formed via Plasma-Enhanced Chemical Vapor Deposition
journal contribution
posted on 2017-10-06, 00:00 authored by Michelle
N. Mann, Ellen R. FisherThe need for low-fouling coatings for biomedical devices has prompted
considerable interest in antibacterial compounds from natural and
sustainable sources, such as essential oils. Herein, a tea tree oil-based
precursor, 1,8-cineole, is used to fabricate antimicrobial films (denoted
ppCin) by plasma-enhanced chemical vapor deposition. Film properties
were comprehensively characterized using a variety of surface and
bulk analytical tools, and the plasma gas phase is assessed using
optical emission spectroscopy, which can be correlated to ppCin film
properties. Notably, film wettability increases linearly with plasma
pressure, yielding water contact angles ranging from ∼50°
to ∼90°. X-ray photoelectron spectroscopy reveals less
oxygen is incorporated at higher pressures, likely arising from the
lower density of OH(g) species. Further, we utilized H2O(v) plasma surface modification of the ppCin films
to improve wettability and find this results in a substantial increase
in surface oxygen content. To elucidate the role of film wettability
and antibacterial properties, both as-deposited and H2O(v) plasma-modified films were exposed to Gram-negative Escherichia coli and Gram-positive Staphylococcus
aureus using glass slides and hydrocarbon films deposited
from 1,7-octadiene as positive controls. Overall, bacteria attach
to a similar extent on all films, including controls, yet only essential
oil-based films significantly prevent biofilm formation (4–7%
coverage compared to ∼40% for controls).
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glass slidesfilm wettabilityplasma-enhanced chemical vapor depositionsurface oxygen contentOHwater contact anglesplasma-modified filmsplasma surface modificationGram-positive Staphylococcus aureusGram-negative Escherichia colihydrocarbon filmsfilm propertiesplasma gas phaseH 2 Ofilm wettability increasesplasma pressurelow-fouling coatingsPlasma-Enhanced Chemical Vapor Depositionemission spectroscopyantimicrobial filmsppCin film propertiestea treeppCin films
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