ol9b02392_si_001.pdf (12.62 MB)
Intramolecular Remote C–H Activation via Sequential 1,4-Palladium Migration To Access Fused Polycycles
journal contribution
posted on 2019-08-15, 15:35 authored by Panpan Li, Qiuyu Li, He Weng, Jiaming Diao, Hequan Yao, Aijun LinAn unprecedented intramolecular remote
C–H activation via
sequential 1,4-palladium migration with an aromatic ring as a conveyor
has been described. This reaction provides an efficient route to construct
diverse polycyclic frameworks in moderate to good yield via palladium-catalyzed
remote C–H activation/alkene insertion, arylation, alkenylation,
and the Heck reaction. The preliminary mechanistic studies revealed
that the 1,4-palladium migration process was reversible.