es7b03875_si_001.pdf (268.31 kB)
Interaction of Human Enteric Viruses with Microbial Compounds: Implication for Virus Persistence and Disinfection Treatments
journal contribution
posted on 2017-11-08, 00:00 authored by Prunelle Waldman, Alba Meseguer, Françoise Lucas, Laurent Moulin, Sébastien WurtzerAlthough the interaction between
phages and bacteria has already
been well described, it only recently emerged that human viruses also
interact with bacteria in the mammalian gut. We studied whether this
interaction could occur in tap water and thus confer enteric viruses
protection against temperature and the classical disinfection treatments
used in drinking water production. We demonstrated that the addition
of lipopolysaccharide or peptidoglycan of bacterial origin to enterovirus
provides thermal protection through stabilization of the viral capsid.
This interaction plays a role when viruses are exposed to disinfection
that targets the capsid, but less so when the virus genome is directly
targeted. The interaction seems to be serotype-specific, suggesting
that the capsid protein sequence could be important. The protection
is linked to a direct association between viral particles and bacterial
compounds as observed by microscopy. These results show that bacterial
compounds present in the environment can affect virus inactivation.