Insecticidal Cyclodepsipeptides from Beauveria felina

Langenfeld, Aude; Blond, Alain; Gueye, Sabelle; Herson, Patrick; Nay, Bastien; Dupont, Joëlle; Prado, Soizic

doi:10.1021/np100890n.s001

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Insecticidal Cyclodepsipeptides from Beauveria felina

2011-04-25T00:00:00Z (GMT) by Aude Langenfeld Alain Blond Sabelle Gueye Patrick Herson Bastien Nay Joëlle Dupont Soizic Prado

A novel cyclodepsipeptide, iso-isariin B (1), and the known isaridin E (2) were isolated from the entomopathogenic fungus Beauveria felina. Their structures were elucidated using MS/MS fragmentation and extensive 2D-heteronuclear NMR. The X-ray structure of isaridin E was obtained, showing two potent intramolecular H bonds and a type-VI turn with the HyLeu¹-Pro² amide bond in a cis conformation. Iso-isariin B (1) was active against the pest-insect Sitophilus spp. with an LD₅₀ value of 10 μg/mL. This observation also gives some clues for ecological interpretation of cyclodepsipeptide production by B. felina.

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cis conformation interpretation intramolecular H bonds entomopathogenic fungus Beauveria felina Sitophilu LD 50 value spp Insecticidal Cyclodepsipeptides HyLeu clue isaridin E fragmentation NMR amide Beauveria felinaA novel cyclodepsipeptide MS cyclodepsipeptide production

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Insecticidal Cyclodepsipeptides from Beauveria felina

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