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Injectable and Near-Infrared-Responsive Hydrogels Encapsulating Dopamine-Stabilized Gold Nanorods with Long Photothermal Activity Controlled for Tumor Therapy
journal contribution
posted on 2019-08-19, 20:14 authored by Jinfeng Zeng, Dongjian Shi, Yanglin Gu, Tatsuo Kaneko, Li Zhang, Hongji Zhang, Daisaku Kaneko, Mingqing ChenGold
nanorods (AuNRs) are confirmed to have excellent and repeated
photothermal properties under near-infrared (NIR)-light irradiation
above 780 nm. However, AuNRs easily leaked out from local pathological
tissues and circulated in the body, reducing photothermal therapy
(PTT) efficacy. By complexing AuNRs with a scaffold via interactions,
AuNRs might be dispersed in the scaffold and fixed in the tumor site.
Thus, based on the mussel-mimetic adhesion concept, AuNRs were designed
to be coated with polydopamine (PDA), and then the prepared polydopamine-coated
AuNRs (AuNR-PDA) were incorporated into a thermosensitive injectable
hydrogel composed of β-glycerophosphate-bound chitosan (CGP)
and dopamine-modified alginate (Alg-DA) efficiently. Due to the strong
interactions between PDA and polymers, AuNR-PDA could be immobilized
stably and evenly into the obtained CGP/Alg-DA/AuNR composite hydrogel,
which can avoid overheating locally or leaking out. The sol–gel
transition temperature of the composite hydrogel was adjusted to the
body temperature at around 37 °C to be conveniently injectable
in vivo. With NIR irradiation at 808 nm of wavelength, the composite
hydrogel was locally heated quickly to over 50 °C depending on
controlling the irradiation powers and times. Moreover, the in vitro
cytotoxicity test of the composite hydrogel showed good biocompatibility
to normal cells but obvious suppression to tumor cells’ growth
under multiple times of photothermal therapy. Furthermore, the in
vivo antitumor test demonstrated the obvious suppression to tumor
growth of the CGP/Alg-DA/AuNR composite hydrogel under multiple PTTs.
Therefore, the injectable CGP/Alg-DA/AuNR hydrogel could be a promising
candidate for the long-term repeated photothermal treatment of tumors.
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Keywords
photothermal therapymussel-mimetic adhesion conceptβ- glycerophosphate-bound chitosanNIRirradiationvivo antitumor testPTTAuNRCGPLong Photothermal Activity ControlledPDATumor Therapy Gold nanorodsthermosensitive injectable hydrogelNear-Infrared-Responsive Hydrogels Encapsulating Dopamine-Stabilized Gold Nanorods
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