ab9b01102_si_002.mp4 (30.08 MB)
Injectable Flexible Subcutaneous Electrode Array Technology for Electrocardiogram Monitoring Device
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posted on 2019-11-14, 21:13 authored by Jihye Bong, Omar Yasin, Vaibhav R. Vaidya, Jeongpil Park, Zachi I. Attia, Deepak Padmanabhan, Sang June Cho, Roshini Asirvatham, Noah Schneider, Juhwan Lee, Eun Mee Kim, Paul A. Friedman, Zhenqiang MaImplantable cardiac monitors have undergone considerable
miniaturization.
However, they continue to be associated with complications such as
infection, bleeding/bruising, and device extrusion or migration. In
this paper, we demonstrate the feasibility of using a small, flexible,
injectable, subcutaneous microelectrode-based device to record electrocardiograms
(ECGs). We describe the fabrication process and demonstrate the ease
of insertion of the injectable ECG device in vivo swine model. We
also demonstrate our device’s high-density channel microelectrode
array’s ability to detect the P, R, and T waves. The amplitude
of these waves showed excellent correlation with distance of the bipolar
electrodes used to detect them. Given the success of our initial studies,
this device has the potential to improve the safety profile of implantable
cardiac monitors and simplify the implantation procedure to allow
for placement in a primary care setting.