jm040013d_si_001.pdf (288.27 kB)
Inhibition of Cytokine Production by Hymenialdisine Derivatives
journal contribution
posted on 2004-07-01, 00:00 authored by Vasudha Sharma, Theresa A. Lansdell, Guangyi Jin, Jetze J. TepeWe describe herein the synthesis and biological activity of two indoloazepines that are
structurally related to the marine sponge metabolite hymenialdisine. The natural product
hymenialdisine was found to be a potent inhibitor of interleukin-2 (IC50 = 2.4 μM) and tumor
necrosis factor α (IC50 = 1.4 μM) production. One of the hymenialdisine derived indoloazepines
was found to also inhibit interleukin-2 (IC50 = 3.5 μM) and tumor necrosis factor α (IC50 = 8.2
μM) production.