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Influence of Molecular Structure on the Properties of Out-of-Equilibrium Oscillating Enzymatic Reaction Networks
journal contribution
posted on 2015-09-30, 00:00 authored by Albert
S. Y. Wong, Sjoerd G. J. Postma, Ilia N. Vialshin, Sergey N. Semenov, Wilhelm T. S. HuckOur knowledge of the properties and
dynamics of complex molecular
reaction networks, for example those found in living systems, considerably
lags behind the understanding of elementary chemical reactions. In
part, this is because chemical reactions networks are nonlinear systems
that operate under conditions far from equilibrium. Of particular
interest is the role of individual reaction rates on the stability
of the network output. In this research we use a rational approach
combined with computational methods, to produce complex behavior (in
our case oscillations) and show that small changes in molecular structure
are sufficient to impart large changes in network behavior.