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In Vivo Study of the Efficacy of the Essential Oil of Zanthoxylum bungeanum Pericarp in Dextran Sulfate Sodium-Induced Murine Experimental Colitis
journal contribution
posted on 2017-04-03, 00:00 authored by Zecai Zhang, Peng Shen, Jiuxi Liu, Cong Gu, Xiaojie Lu, Yanxin Li, Yongguo Cao, Bo Liu, Yunhe Fu, Naisheng ZhangThe
purpose of this study was to investigate the protective effects
and mechanisms of the essential oil of Zanthoxylum bungeanum pericarp (ZBEO) on dextran sulfate sodium (DSS)-induced experimental
colitis in mice. ZBEO decreased DSS-induced body weight loss, the
disease activity index, colon length shortening, colonic pathological
damage, and myeloperoxidase activities. The production of pro-inflammatory
mediators was significantly alleviated by ZBEO. Further mechanistic
analysis showed that ZBEO inhibited inflammation by regulating NF-κB
and PPARγ pathways. ZBEO also inhibited NLRP3 activation in
colitis in mice. Furthermore, ZBEO contributed to the maintenance
of tight junction architecture by regulating the expression of zonula
occludens-1 during colitis. Surprisingly, treatment with ZBEO increased
levels of the commensal bacteria containing Lactobacillus and Bifidobacteria but reduced Escherichia
coli levels in the feces of mice. These results suggested
that supplementation with ZBEO might provide a new dietary strategy
for the prevention of ulcerative colitis.
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Zanthoxylum bungeanum PericarpZanthoxylum bungeanum pericarpdisease activity indexzonula occludenscolitipro-inflammatory mediatorsmyeloperoxidase activitiesEssential OilNLRP 3 activationdextran sulfate sodiumVivo StudyEscherichia coli levelsjunction architectureZBEOPPAR γ pathwayscommensal bacteriacolon lengthDSS-induced body weight lossNF -κBDextran Sulfate Sodium-Induced Murine
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