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In Situ Synthesis of Amino Acid Functionalized Carbon Dots with Tunable Properties and Their Biological Applications
journal contribution
posted on 2019-07-17, 18:37 authored by Subrata Pandit, Pradipta Behera, Jagabandhu Sahoo, Mrinmoy DeEmissive
carbon dots (C-Dots) are known for displaying versatile
properties, which have been widely utilized in many applications such
as bioimaging, light-emitting devices, and photocatalysis. Further
functionalization can tune their physical and chemical properties,
which play the key role in many biologically and chemically relevant
applications. Amino acids provide an attractive means for introducing
functionality with a structural diversity. In this work, water-soluble
emissive C-Dots were synthesized from pyrolysis of citric acid in
the presence of various amino acids under hydrothermal conditions.
We established that the diverse functionality-bearing polyamides and
the polyester backbone of C-Dots are the origin of optical properties
with a high quantum yield. The amino acid based C-Dots were systematically
characterized using various analytical methods to confirm the core
structure as well as the functionality. The results show that, depending
on functionalization, the quantum yield can be varied and enhanced
up to 62% and surface charge and hydrophobicity can be tuned. Most
importantly, we observed a correlation between the quantum yield and
properties of the side chain residue of amino acids such as hydrophobicity
index and volume. Furthermore, it was found that the synthesized,
diversely functionalized C-Dots exhibit no cellular toxicity and can
be used for cell imaging. Due to variable surface functionality, we
have also applied these C-Dots for array-based protein sensing. Overall,
based on this reported method, we can easily tune the optical as well
as surface properties of C-Dots, which will be suitable for many future
applications.
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Amino acidscell imagingcore structurequantumresults showTunable Propertiesemissive C-Dotsfunctionality-bearing polyamidessurface functionalitychemical propertiesside chain residuesurface propertiesdiversely functionalized C-Dots exhibitarray-based proteinsurface chargehydrothermal conditionsBiological Applications Emissive carbon dotsfuture applicationspolyester backbonehydrophobicity indexlight-emitting devicesFunctionalized Carbon DotsSitu Synthesis
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