In Situ Catalyst Generation and Benchtop-Compatible
Entry Points for TiII/TiIV Redox Catalytic Reactions

Davis-Gilbert, Zachary
W.; Kawakita, Kento; Blechschmidt, Daniel R.; Tsurugi, Hayato; Mashima, Kazushi; Tonks, Ian A.

doi:10.1021/acs.organomet.8b00474.s001

om8b00474_si_001.pdf (1.47 MB)

In Situ Catalyst Generation and Benchtop-Compatible Entry Points for Ti^II/Ti^IV Redox Catalytic Reactions

journal contribution

posted on 2018-09-06, 17:49 authored by Zachary W. Davis-Gilbert, Kento Kawakita, Daniel R. Blechschmidt, Hayato Tsurugi, Kazushi Mashima, Ian A. Tonks

The development of several in situ generated catalyst systems for Ti-catalyzed oxidative nitrene transfer reactions is reported. The simplest and widely applicable catalyst system, TiCl₄(THF)₂/Zn⁰, can be set up on the benchtop under air. This system uses commercially available reagents and can be used as an entry point for Ti^II/Ti^IV multicomponent redox reactions for the synthesis of pyrroles, α,γ-unsaturated imines, α,β-unsaturated imines, cyclopropylimines, and arenes.