op100100y_si_001.pdf (1.06 MB)
Improved Process for the Preparation of 1-Benzhydrylazetidin-3-ol: Development of an Efficient Synthesis and Identification of Process-related Impurities and/or Intermediates
journal contribution
posted on 2010-07-16, 00:00 authored by V. V. R. M. Krishna Reddy, K. Kishore Babu, A. Ganesh, P. Srinivasulu, G. Madhusudhan, K. MukkantiAn improved, one-pot, and multikilogram-scale synthesis of 1-benzhydrylazetidin-3-ol, the pharmaceutically important moiety, has been developed. The improved process for the preparation of 1-benzhydrylazetidin-3-ol was able to minimize a content of impurities and allows the effective production of 1-benzhydrylazetidin-3-ol and its scale-up. The process was high yielding (80%) and chromatography-free with purity 99.3 area %.
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