am7b15677_si_001.pdf (7.32 MB)
Identification of Novel “Inks” for 3D Printing Using High-Throughput Screening: Bioresorbable Photocurable Polymers for Controlled Drug Delivery
Version 2 2018-02-15, 12:33
Version 1 2018-01-25, 16:24
journal contribution
posted on 2018-01-11, 00:00 authored by Iria Louzao, Britta Koch, Vincenzo Taresco, Laura Ruiz-Cantu, Derek J. Irvine, Clive J. Roberts, Christopher Tuck, Cameron Alexander, Richard Hague, Ricky Wildman, Morgan R. AlexanderA robust
methodology is presented to identify novel biomaterials suitable for
three-dimensional (3D) printing. Currently, the application of additive
manufacturing is limited by the availability of functional inks, especially
in the area of biomaterials; this is the first time when this method
is used to tackle this problem, allowing hundreds of formulations
to be readily assessed. Several functional properties, including the
release of an antidepressive drug (paroxetine), cytotoxicity, and
printability, are screened for 253 new ink formulations in a high-throughput
format as well as mechanical properties. The selected candidates with
the desirable properties are successfully scaled up using 3D printing
into a range of object architectures. A full drug release study and
degradability and tensile modulus experiments are presented on a simple
architecture to validating the suitability of this methodology to
identify printable inks for 3D printing devices with bespoke properties.
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high-throughput formatHigh-Throughput Screeningink formulationsantidepressive drugobject architectures3 D PrintingmethodologyBioresorbable Photocurable PolymersControlled Drug Delivery3 D printing devicesmodulus experiments3 D printingdrug release studyadditive manufacturingnovel biomaterialsbespoke properties
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