jo500691b_si_001.pdf (2.89 MB)
Hypervalent Iodine-Promoted α‑Fluorination of Acetophenone Derivatives with a Triethylamine·HF Complex
journal contribution
posted on 2014-06-20, 00:00 authored by Tsugio Kitamura, Kensuke Muta, Kazutaka MutaThe direct fluorination reaction
of acetophenone using iodosylarenes
and TEA·5HF was conducted under mild conditions except for use
of a HF reagent. The fluorination reaction was applied to acetophenone
derivatives, acetonaphthones, benzyl phenyl ketone, propiophenone,
butyrophenone, 1-indanone, and phenacyl chloride, giving selectively
the corresponding α-fluoroketone derivatives in good yields.