Hypervalent Iodine-Promoted α‑Fluorination of Acetophenone Derivatives with a Triethylamine·HF Complex
2014-06-20T00:00:00Z (GMT) by
The direct fluorination reaction of acetophenone using iodosylarenes and TEA·5HF was conducted under mild conditions except for use of a HF reagent. The fluorination reaction was applied to acetophenone derivatives, acetonaphthones, benzyl phenyl ketone, propiophenone, butyrophenone, 1-indanone, and phenacyl chloride, giving selectively the corresponding α-fluoroketone derivatives in good yields.
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