Hypervalent Iodine Mediated
Synthesis of C‑2 Deoxy Glycosides
and Amino Acid Glycoconjugates

Islam, Maidul; Tirukoti, Nishanth D.; Nandi, Shyamapada; Hotha, Srinivas

doi:10.1021/jo500465m.s001

jo500465m_si_001.pdf (3 MB)

Hypervalent Iodine Mediated Synthesis of C‑2 Deoxy Glycosides and Amino Acid Glycoconjugates

journal contribution

posted on 2014-05-16, 00:00 authored by Maidul Islam, Nishanth D. Tirukoti, Shyamapada Nandi, Srinivas Hotha

A simple, efficient, and practical method for the synthesis of C-2 deoxy-2-iodo glycoconjugates in self-assembled structures was found using PhI(OCOR)₂. 2-Iodo glycoserinyl esters were intramolecularly converted into 2-iodo serinyl glycosides which upon dehalogenation gave C-2 deoxy amino acid glycoconjugates.