bc060060f_si_001.pdf (541.55 kB)
Hydrogels Formed by Multiple Peptide Ligation Reactions To Fasten Corneal Transplants
journal contribution
posted on 2006-07-19, 00:00 authored by Michel Wathier, C. Starck Johnson, Terry Kim, Mark W. GrinstaffA stable cross-linked hydrogel was formed under mild aqueous conditions using pseudoproline peptide ligation
chemistry. A cysteine-terminated lysine dendron containing four cysteines and a PEG macromolecule modified
with terminal ester aldehydes were prepared. Upon mixing, the two macromers gave a stable hydrogel. This
hydrogel along with sutures was used to successfully secure a corneal transplant in vitro.