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Highly Sensitive Detection of Physiological Spins in a Microfluidic Device
journal contribution
posted on 2013-09-11, 00:00 authored by Florestan C. Ziem, Nicolas S. Götz, Andrea Zappe, Steffen Steinert, Jörg WrachtrupSensing and imaging paramagnetic
species under physiological conditions
is a key technology in chemical and biochemical analytics, cell biology,
and medical sciences. At submicrometer length scales, nitrogen-vacancy
(NV) centers in diamond offer atom-sized probes for magnetic fields.
We show that spin relaxation of an ensemble NV sensor allows sensing
of adsorbed and freely diffusing manganese(II) ions and adsorbed ferritin.
Sensitivities approach 175 Mn ions and 10 ferritin proteins per diffraction
limited spot under ambient conditions.