cs8b00827_si_001.pdf (8.92 MB)
Highly Enantioselective Synthesis of Chiral γ‑Lactams by Rh-Catalyzed Asymmetric Hydrogenation
journal contribution
posted on 2018-04-23, 00:00 authored by Qiwei Lang, Guoxian Gu, Yaoti Cheng, Qin Yin, Xumu ZhangA Rh/bisphosphine-thiourea
(ZhaoPhos) catalytic system has been
identified for the straightforward asymmetric synthesis of chiral
γ-lactams. A variety of NH free α,β-unsaturated
lactams bearing a β-aryl or β-alkyl substituent were smoothly
hydrogenated to provide the desired γ-lactams in up to 99% yield
and 99% enantiomeric excess (ee). This methodology provides a highly
practical pathway to synthesize chiral γ-lactams or γ-amino
acids.