posted on 2020-03-23, 17:14authored byWenbo Liu, Jun Guo, Shipei Xing, Zhan Lu
A highly
enantioselective cobalt-catalyzed hydroboration of diaryl
ketones with pinacolborane was developed using chiral imidazole iminopyridine
as a ligand to access chiral benzhydrols in good to excellent yields
and ee. This protocol could be carried out in a gram scale under mild
reaction conditions with good functional group tolerance. Chiral biologically
active 3-substituted phthalide and (S)-neobenodine
could be easily constructed through asymmetric hydroboration as a
key step.