Highly Enantioselective 3-Furylation of Ketones Using (3-Furyl)titanium Nucleophile

A novel asymmetric 3-furyl addition of (3-furyl)Ti(OⁱPr)₃ to ketones in the presence of 10 mol % (S)-BINOL is reported. The catalytic system works excellently for aromatic ketones, α- or β-halophenones, α,β-unsaturated ketones, and acetylfuran, affording products in high yields with excellent enantioselectivities of up to 97% ee.