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Highly Efficient Multigram Synthesis of Dibenzoazacyclooctyne (DBCO) without Chromatography
journal contribution
posted on 2019-11-12, 17:36 authored by Stuart
A. McNelles, Julia L. Pantaleo, Alex AdronovThe synthesis of
4-[11,12-didehydrodibenzo[b,f]azocin-5(6H)-yl]-4-oxobutanoic acid,
also known as dibenzoazacyclooctyne (DBCO) or aza-dibenzocyclooctyne
(ADIBO), was optimized for large-scale preparations of at least 10
g with an overall yield of 42%.