ol006739v_si_001.pdf (52.51 kB)
High-Yielding Staudinger Ligation of a Phosphinothioester and Azide To Form a Peptide
journal contribution
posted on 2000-12-19, 00:00 authored by Bradley L. Nilsson, Laura L. Kiessling, Ronald T. RainesThe Staudinger ligation can be used to couple a peptide with a C-terminal phosphinothioester to another with an N-terminal α-azido group to
form a single peptide that contains no residual atoms. Here, diphenylphosphinomethanethiol thioesters are shown to give high isolated yields
for this transformation. This finding provides precedent for a powerful and versatile new method for the total synthesis of proteins.