jf7b03382_si_001.pdf (87.9 kB)
Gypenosides Reduced the Risk of Overweight and Insulin Resistance in C57BL/6J Mice through Modulating Adipose Thermogenesis and Gut Microbiota
journal contribution
posted on 2017-10-04, 00:00 authored by Jie Liu, Yanfang Li, Puyu Yang, Jianchun Wan, Qimeng Chang, Thomas T. Y. Wang, Weiying Lu, Yaqiong Zhang, Qin Wang, Liangli Lucy YuThis study investigated whether and
how gypenosides from jiaogulan
tea at 100 and 300 mg/kg/day levels could reduce the development of
overweight and insulin resistance in C57 BL/6J mice fed a high-fat
diet in 12 weeks. The 300 mg/kg/day gypenosides supplement significantly
reduced final body weight, plasma total cholesterol, and homeostasis
model assessment-estimated insulin resistance (HOMA-IR) index by 19.9%,
40%, and 36%, respectively, compared with the high-fat diet control
group. Gypenosides also increased brown adipocyte tissue activity
and white adipose tissue browning. The expression of genes involved
in mitochondrial activity and fatty acid β-oxidation were also
increased in both brown and white adipocyte tissues. In addition,
gypenosides at 100 and 300 mg/kg/day levels decreased the ratio of Firmicutes to Bacteroidetes by 20% and
58.6%, respectively, and increased Akkermansia muciniphila abundance in the gut microbiota.
History
Usage metrics
Categories
Keywords
jiaogulan teagypenosideadipocyte tissues12 weeksadipose tissuehigh-fat diet control groupgut microbiotainsulin resistancebody weightHOMA-IRC 57BL Micemgmitochondrial activityGypenosides Reducedhigh-fat dietGut MicrobiotaInsulin Resistanceadipocyte tissue activityacid β- oxidationModulating Adipose Thermogenesishomeostasis model assessment-estimated insulin resistanceAkkermansia muciniphila abundance
Licence
Exports
RefWorks
BibTeX
Ref. manager
Endnote
DataCite
NLM
DC