Gold Nanoparticles Inhibit
VEGF165-Induced Proliferation of
HUVEC Cells

Bhattacharya, R.; Mukherjee, P.; Xiong, Z.; Atala, A.; Soker, S.; Mukhopadhyay, D.

doi:10.1021/nl0483789.s001

nl0483789_si_001.pdf (101.08 kB)

Gold Nanoparticles Inhibit VEGF165-Induced Proliferation of HUVEC Cells

journal contribution

posted on 2004-12-08, 00:00 authored by R. Bhattacharya, P. Mukherjee, Z. Xiong, A. Atala, S. Soker, D. Mukhopadhyay

Gold nanoparticles inhibit VEGF165, a heparin binding growth factor, induced proliferation of HUVEC cells but do not interfere with the activity of VEGF121, a non-heparin binding growth factor. The interaction between gold nanoparticles and VEGF165 primarily occurs through the heparin binding domain of the protein. VEGF121 does not have a heparin binding domain and hence is not inactivated by gold nanoparticles.