Gold-Catalyzed Intramolecular
Cyclization of N‑Propargylic β‑Enaminones
for the Synthesis
of 1,4-Oxazepine Derivatives

Goutham, Kommuru; Kumar, Desamala Ashok; Suresh, Surisetti; Sridhar, Balasubramanian; Narender, Ravirala; Karunakar, Galla V.

doi:10.1021/acs.joc.5b01733.s002

jo5b01733_si_002.pdf (2.48 MB)

Gold-Catalyzed Intramolecular Cyclization of N‑Propargylic β‑Enaminones for the Synthesis of 1,4-Oxazepine Derivatives

journal contribution

posted on 2015-11-06, 00:00 authored by Kommuru Goutham, Desamala Ashok Kumar, Surisetti Suresh, Balasubramanian Sridhar, Ravirala Narender, Galla V. Karunakar

An efficient and mild one-pot, gold-catalyzed intramolecular cyclization of N-propargylic β-enaminones has been achieved for the generation of 1,4-oxazepine derivatives. This synthetic transformation tolerates a range of substituted N-propargylic β-enaminones in moderate to good yields.