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Glucose Oxidase–Polymer Nanogels for Synergistic Cancer-Starving and Oxidation Therapy
journal contribution
posted on 2017-06-26, 00:00 authored by Wenguo Zhao, Jin Hu, Weiping GaoGlucose
oxidase (GOX) can convert glucose into gluconic acid and hydrogen
peroxide (H2O2), which is potentially useful
for synergistic cancer-starving and oxidation therapy. Herein we demonstrate
a glucose-responsive nanomedicine made of GOX–polymer nanogels
to regulate H2O2 production for synergistic
melanoma starving and oxidation therapy. GOX–polymer nanogels
showed glucose-responsive H2O2-generating activity
in vitro, improved stability, and considerably enhanced tumor retention
as compared to native GOX. More importantly, they exhibited high antimelanoma
efficacy and no obvious systemic toxicity, whereas native GOX was
ineffective and systemically toxic at the same dose. This work paves
the way for establishing an endogenous and noninvasive cancer treatment
paradigm that is based on intratumoral glucose-responsive, H2O2-generating chemical reactions.