np2009626_si_001.pdf (709.94 kB)
Geranylphenazinediol, an Acetylcholinesterase Inhibitor Produced by a Streptomyces Species
journal contribution
posted on 2012-07-27, 00:00 authored by Birgit Ohlendorf, Dirk Schulz, Arlette Erhard, Kerstin Nagel, Johannes F. ImhoffGeranylphenazinediol (1), a new phenazine
natural
product, was produced by the Streptomyces sp. strain
LB173, which was isolated from a marine sediment sample. The structure
was established by analysis of NMR and MS data. 1 inhibited
the enzyme acetylcholinesterase in the low micromolar range and showed
weak antibacterial activity. In order to get a more detailed picture
of the activity profile of 1, its inhibitory potential
was compared to that of related structures.