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Functionalized Multiarmed Polycaprolactones as Biocompatible Tissue Adhesives

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journal contribution
posted on 2020-03-31, 21:13 authored by Wei Zhang, Tianjiao Ji, Sophie Lyon, Manisha Mehta, Yueqin Zheng, Xiaoran Deng, Andong Liu, Alona Shagan, Boaz Mizrahi, Daniel S. Kohane
Existing tissue adhesives have a trade-off between adhesive strength and biocompatibility. Here, we report a series of biocompatible multiarmed polycaprolactones (PCL) as tissue adhesives that can be released from a hot glue gun and the length of each arm was kept at ∼2–3 kg mol–1 in all the polymers. The adhesion properties were dependent on the number of functionalized (N-hydroxysuccinimide ester (NHS), aldehyde (CHO), and isocyanate (NCO)) arms of the multiarmed polymers. The more arms, the higher the adhesion strength. For example, the adhesion strength in binding cut rat skin increased from 2.3 N cm–2 for 2PCL-NHS to 11.2 N cm–2 for 8-PCL-NHS. CHO- and NCO-modified 8PCL also had suitable adhesive properties. All the multiarmed polymers had minimal cytotoxicity in vitro and good biocompatibility in vivo, suggesting their potential as promising alternative surgical adhesives.

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