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Functional Carboxymethylcellulose/Zein Bionanocomposite Films Based on Neomycin Supported on Sepiolite or Montmorillonite Clays
journal contribution
posted on 2018-10-18, 17:48 authored by Ediana
P. Rebitski, Ana C. S. Alcântara, Margarita Darder, Rogério L. Cansian, Luis Gómez-Hortigüela, Sibele B. C. PergherThe
present work introduces new functional bionanocomposite materials
based on layered montmorillonite and fibrous sepiolite clays and two
biopolymers (carboxymethylcellulose polysaccharide and zein protein)
to produce drug-loaded bionanocomposite films for antibiotic topical
delivery. Neomycin, an antibiotic indicated for wound infections,
was employed as the model drug in this study. The physical properties
and the antimicrobial activity of these materials were evaluated as
a function of the type of hybrid and the amount of zein protein incorporated
in the bionanocomposite films. In addition, the interfacial and physicochemical
properties of these new clay–drug hybrids have been studied
through a combination of experimental and computational methodologies,
where the computational studies confirm the intercalation of neomycin
into the montmorillonite layers and the possible penetration of the
drug in the tunnels of sepiolite, as pointed out by N2 adsorption
and X-ray diffraction techniques. The antimicrobial activity of these
bionanocomposite materials show that the films based on montmorillonite–neomycin
display a more pronounced inhibitory effect of the bacterial growth
than those prepared with the sepiolite–neomycin hybrid. Such
effect can be related to the difficult release of neomycin adsorbed
on sepiolite due to a strong interaction between both components.