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From Tetrahydrofurans to Tetrahydrobenzo[d]oxepines via a Regioselective Control of Alkyne Insertion in Rhodium-Catalyzed Arylative Cyclization

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journal contribution
posted on 2019-03-20, 00:00 authored by Aymane Selmani, Fabien Serpier, Sylvain Darses
The formation of chiral 5- and 7-membered tetrahydrofurans and tetrahydrobenzo­[d]­oxepines is achieved via arylative cyclization of simple O-tethered alkyne-enoates in the presence of arylboronic acids and chiral dienes-rhodium catalyst under mild conditions. Access to such structures was achieved via a simple switch in the regioselectivity of the alkyne insertion thanks to a proper choice of the alkyne substituent.

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