From Tetrahydrofurans to Tetrahydrobenzo[d]oxepines via a Regioselective Control of Alkyne Insertion in Rhodium-Catalyzed Arylative Cyclization
2019-03-20T00:00:00Z (GMT) by
The formation of chiral 5- and 7-membered tetrahydrofurans and tetrahydrobenzo[d]oxepines is achieved via arylative cyclization of simple O-tethered alkyne-enoates in the presence of arylboronic acids and chiral dienes-rhodium catalyst under mild conditions. Access to such structures was achieved via a simple switch in the regioselectivity of the alkyne insertion thanks to a proper choice of the alkyne substituent.
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