ac9b04526_si_003.pdf (183.47 kB)
Free Flow Ion Concentration Polarization Focusing (FF-ICPF)
journal contribution
posted on 2020-03-27, 21:44 authored by Vasileios A. Papadimitriou, Loes I. Segerink, Jan C. T. EijkelElectrokinetic
separation techniques in microfluidics are a powerful
analytical chemistry tool, although an inherent limitation of microfluidics
is their low sample throughput. In this article we report a free-flow
variant of an electrokinetic focusing method, namely ion concentration
polarization focusing (ICPF). The analytes flow continuously through
the system via pressure driven flow while they separate and concentrate
perpendicularly to the flow by ICPF. We demonstrate free flow ion
concentration polarization focusing (FF-ICPF) in two operating modes,
namely peak and plateau modes. Additionally, we showed the separation
resolution could be improved by the use of an electrophoretic spacer.
We report a concentration factor of 10 in human blood plasma in continuous
flow at a flow rate of 15 μL min–1.
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analytes flowFF-ICPFFree Flow Ion Concentration Polarizationseparation resolutionchemistry toolconcentration factorflow ratesample throughputplateau modesfree-flow variantblood plasmaElectrokinetic separation techniquesion concentration polarizationICPFelectrophoretic spacerflow ion concentration polarization
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