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Framework toward More Sustainable Chemical Synthesis DesignA Case Study of Organophosphates
journal contribution
posted on 2019-02-25, 00:00 authored by Michael A. Gonzalez, Sudhakar Takkellapati, Kidus Tadele, Tao Li, Rajender S. VarmaIn
recent years, the advancement of sustainable chemistry concepts
and approaches along with their demonstrated application has become
a central part of the design, synthesis, and manufacture of a chemical.
Sustainable chemistry not only utilizes the principles of green chemistry,
but also expands to incorporate economic, societal, and environmental
aspects. This is further elucidated by the incorporation of life cycle
assessment/thinking to include the raw material production, manufacture,
processing, use, and disposal stages, allowing for a comprehensive
evaluation of the environmental and human health impacts attributed
to a chemical. This contribution outlines an approach for the development
of a preliminary framework for the sustainable synthesis of a chemical
that is identified as an alternative for an existing chemical of concern.
The framework is introduced concurrently with a case study for organophosphates
that are selected as potential replacements for brominated flame retardants
(BFRs). This framework is designed to apply existing knowledge of
green chemistry to the synthesis of alternatives, along with its integration
into Life Cycle Assessment culminating in the development of a more
overall sustainable chemical entity when compared to its predecessor.