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Four-Component Reaction of N-Sulfonylimines, (Cyanomethylene)triphenylphosphorane, Nitromethane, and Formaldehyde for the Synthesis of 3-Substituted 2-Methylene-4-nitrobutanenitriles

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journal contribution
posted on 2011-05-20, 00:00 authored by Yin-Huan Jin, Fan Fang, Xiang Zhang, Qing-Zhou Liu, Hao-Bo Wang, Shi-Kai Tian
An efficient four-component synthesis of 3-substituted 2-methylene-4-nitrobutanenitriles has been developed from N-sulfonylimines, (cyanomethylene)triphenylphosphorane, nitromethane, and formaldehyde in the absence of catalysts and additives at room temperature.

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