Formation of Substituted Tetrahydropyrans through Oxetane Ring Opening: Application to the Synthesis of C1–C17 Fragment of Salinomycin
2014-02-07T00:00:00Z (GMT)
by
The stereoselective
synthesis of C1–C17 fragment of salinomycin is achieved. The
strategy employs a desymmetrization approach and utilizes an intramolecular
oxetane opening reaction with O-nucleophile to result
in the tetrahydropyran skeleton as the key step.