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Formation of Substituted Tetrahydropyrans through Oxetane Ring Opening: Application to the Synthesis of C1–C17 Fragment of Salinomycin
journal contribution
posted on 2014-02-07, 00:00 authored by J. S. Yadav, Vinay
K. Singh, P. SrihariThe stereoselective
synthesis of C1–C17 fragment of salinomycin is achieved. The
strategy employs a desymmetrization approach and utilizes an intramolecular
oxetane opening reaction with O-nucleophile to result
in the tetrahydropyran skeleton as the key step.