ja500118w_si_002.cif (16.44 kB)
Formal Carbene Insertion into C–C Bond: Rh(I)-Catalyzed Reaction of Benzocyclobutenols with Diazoesters
dataset
posted on 2014-02-26, 00:00 authored by Ying Xia, Zhenxing Liu, Zhen Liu, Rui Ge, Fei Ye, Mohammad Hossain, Yan Zhang, Jianbo WangA Rh(I)-catalyzed formal carbene
insertion into C–C bond
of benzocyclobutenols has been realized by employing diazoesters as
carbene precursors. The product indanol derivatives were obtained
in good yields and in diastereoselective manner under mild reaction
conditions. All-carbon quaternary center is constructed at the carbenic
carbon. This catalytic reaction involves selective cleavage of C–C
bond, Rh(I) carbene insertion, and intramolecular aldol reaction.
