jo900449a_si_003.cif (14.27 kB)

Fluoride Ion and Phosphines as Nucleophilic Catalysts: Synthesis of 1,4-Benzothiazepines from Cyclic Sulfenamides

dataset

posted on 2009-05-15, 00:00 authored by Cédric Spitz, Jean-François Lohier, Jana Sopkova-de Oliveira Santos, Vincent Reboul, Patrick Metzner

A new methodology, using fluoride ion as a nucleophilic catalyst, was applied for the synthesis of enantiopure 1,4-benzothiazepine from cyclic sulfenamide and electron-deficient acetylene, with high efficiency and atom economy.

History

Usage metrics

Keywords

Benzothiazepine acetylene atom economy fluoride ion Phosphine benzothiazepine methodology nucleophilic catalyst cyclic sulfenamide Fluoride Ion Nucleophilic Catalysts efficiency enantiopure Synthesi Cyclic Sulfenamides synthesis

Licence

CC BY-NC 4.0

Exports

RefWorks

BibTeX

Ref. manager

Endnote

DataCite

NLM