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Flavipesides A–C, PKS-NRPS Hybrids as Pancreatic Lipase Inhibitors from a Marine Sponge Symbiotic Fungus Aspergillus flavipes 164013
journal contribution
posted on 2020-02-14, 15:14 authored by Wei-Hua Jiao, Qi-Hang Xu, Guang-Bo Ge, Ru-Yi Shang, Hong-Rui Zhu, Hong-Yan Liu, Jie Cui, Fan Sun, Hou-Wen LinThree
unusual chlorinated PKS-NRPS hybrid metabolites, flavipesides
A–C (1–3), were isolated from
a strain of marine sponge symbiotic fungus Aspergillus flavipes 164013. Their structures were determined by spectroscopic data analysis,
and absolute configurations were assigned by single-crystal X-ray
diffraction with ECD spectral analysis. Flavipesides A–C showed
potent pancreatic lipase (PL) inhibitory activity with IC50 values of 0.07–0.23 μM.
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spectroscopic data analysisHybridstrainconfigurationPancreatic Lipase InhibitorsFlavipesideMarine Sponge Symbiotic Fungus Aspergillus flavipes 164013ECDIC 50 valuespancreatic lipaseflavipesidechlorinated PKS-NRPSmetabolitefungus Aspergillus flavipes 164013.PLmarine spongesingle-crystal X-ray diffraction
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