ol047332j_si_001.pdf (65.7 kB)
First Enantiospecific Synthesis of the Antitumor Marine Sponge Metabolite (−)-15-Oxopuupehenol from (−)-Sclareol
journal contribution
posted on 2005-04-14, 00:00 authored by E. J. Alvarez-Manzaneda, R. Chahboun, I. Barranco Pérez, E. Cabrera, E. Alvarez, R. Alvarez-ManzanedaA new route toward puupehenone-related bioactive metabolites from (−)-sclareol, based on the palladium(II)-mediated diastereoselective cyclization
of a drimenylphenol, is described. Utilizing this, the first enantiospecific synthesis of the antitumor and antimalarial (−)-15-oxopuupehenol,
together with improved syntheses of (+)-puupehenone, (+)-puupehedione, and (+)-15-cyanopuupehenone, were accomplished.