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Ferrocene Functionalized Upconversion Nanoparticle Nanosystem with Efficient Near-Infrared-Light-Promoted Fenton-Like Reaction for Tumor Growth Suppression
journal contribution
posted on 2020-05-25, 04:44 authored by Jimin Zhou, Xiangfeng Zhu, Qianya Cheng, Yuxuan Wang, Ruiqi Wang, Xingwen Cheng, Jiajia Xu, Kuntang Liu, Lin Li, Xueming Li, Mingfang He, Jian Wang, Heng Xu, Su Jing, Ling HuangBy taking advantage
of the efficient Förster resonance energy
transfer (FRET) between near-infrared (NIR)-responsive lanthanide-doped
upconversion nanoparticles (UCNPs) and Fenton reagent ferrocenyl compounds
(Fc), a series of Fc-UCNPs was designed
by functionalizing NaYF4:Yb,Tm nanoparticles with Fc1–Fc5 via surface-coordination
chemistry. Fc-UCNP-Lipo nanosystems were then constructed
by encapsulating Fc-UCNP inside liposomes for efficient
delivery. Fc-UCNP can effectively release ·OH via a NIR-promoted Fenton-like reaction. In vitro and in vivo studies of Fc1-UCNP-Lipo
confirmed the preferential accumulation in a tumor site followed by
an enhanced uptake of cancer cells. After cellular internalization,
the released Fc1-UCNP can effectively promote ·OH
generation for tumor growth suppression. Such a Fc1-UCNP-Lipo
nanosystem exhibits advantages such as easy fabrication, low drug
dosage, and no ferrous ion release.
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Fenton reagent ferrocenyl compoundsOHTumor Growth Suppressionferrous ion releasefunctionalizing NaYF 4Fc 1Ferrocene Functionalized Upconversion Nanoparticle Nanosystemtumor growth suppressionFRETUCNP-Lipo nanosystem exhibits advantagesNIR-promoted Fenton-like reactionEfficient Near-Infrared-Light-Promoted Fenton-Like Reaction
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