ol0c00123_si_001.pdf (2.26 MB)
Fe-Catalyzed Domino Intramolecular Nucleophilic Substitution of 4‑Hydroxychromen-2-one and Pyran-2-one/Ring Opening of Activated Arene: An Easy Access to 2,3-Disubstituted Furo[3,2,‑c]coumarins and Furo[3,2,‑c]pyran-4-ones via Nonsymmetric Triarylmethanes
journal contribution
posted on 2020-02-25, 14:05 authored by Wayland E. Noland, Honnaiah Vijay Kumar, Arjun Sharma, Binyuan Wei, Selamawit GirmachewA one-pot synthesis
of functionalized 2,3-disubstituted furo[3,2,-c]coumarins
and furo[3,2,-c]pyran-4-ones under hydrated ferric
sulfate catalysis was performed. It was revealed that the reaction
proceeds with intramolecular cyclofunctionalization of nonsymmetric
triarylmethanes via ring opening of 2-methylfuran followed by recyclization,
resulting in the selective formation of desired products. The versatility
of this method was demonstrated via the succinct synthesis of an anticoagulant
agent analogue and 2,3-disubstituted benzofurans.
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functionalizedone-pot synthesisHydroxychromenNonsymmetric Triarylmethanesfurocoumarinrecyclizationnonsymmetric triarylmethanesversatilitybenzofuranmethod2- methylfuranreaction proceedsDisubstitutedformationEasy AccessActivated Arenepyran -4-onesPyran -2-oneferric sulfate catalysisFe-Catalyzed Domino Intramolecular Nucleophilic Substitutionintramolecular cyclofunctionalizationdisubstitutedring openinganticoagulant agent analogueFuro
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