ao8b00966_si_001.pdf (1.37 MB)
Faster and Greener Chemical Reaction Workup Using Silicone Elastomer-Coated Glass Powders
journal contribution
posted on 2018-06-21, 11:33 authored by Zhenyu Shi, Gerald B. Hammond, Bo XuWe
have developed a substantially faster and greener technique
for routine chemical reaction workups. We use silicone elastomer-coated
glass powder (“FastWoRX”) as an absorbent to extract
organic products from a quenched aqueous reaction mixture. After filtration,
FastWoRX powder loaded with organic products can serve as a convenient
input for flash chromatographic separations. With this technique,
tedious and solvent-consuming liquid–liquid extractions are
replaced by a simple filtration. Use of FastWoRX reduces solvent use
and the E-factor by up to an order of magnitude compared
to traditional liquid–liquid extraction-based workup.