cg9b00568_si_001.pdf (794.03 kB)
Family of Conglomerate-Forming Systems Composed of Chlocyphos and Alkyl-amine. Assessment of Their Resolution Performances by Using Various Modes of Preferential Crystallization
journal contribution
posted on 2019-08-22, 14:35 authored by Aliou Mbodji, Gabin Gbabode, Morgane Sanselme, Nicolas Couvrat, Michel Leeman, Valérie Dupray, Richard M. Kellogg, Gérard CoquerelThe present study
aimed at screening conglomerate derivatives of racemic chlocyphos
(4-(2-chlorophenyl)-5,5-dimethyl-2-hydroxy-1,3,2-dioxaphosphorinane
2-oxide) and to perform enantiomeric separation by preferential crystallization.
A list of more than 20 chlocyphos salt derivatives were characterized
by various techniques (SHG, DSC, and X-ray powder diffraction). A
family of salts formed with various alkyl amines crystallizing as
conglomerates is evidenced. The first attempts to resolve these conglomerates
by preferential crystallization at small scale were successful. The
mitigated performances of these entrainments are discussed.