ol5019079_si_001.pdf (2.48 MB)
Facile Access to Functionalized Spiro[indoline-3,2′-pyrrole]-2,5′-diones via Post-Ugi Domino Buchwald–Hartwig/Michael Reaction
journal contribution
posted on 2014-08-01, 00:00 authored by Nandini Sharma, Zhenghua Li, Upendra K. Sharma, Erik V. Van der EyckenA novel access to spiro[indoline-3,2′-pyrrole]-2,5′-diones
is presented via a palladium-catalyzed post-Ugi cascade cyclization
approach involving a Buchwald–Hartwig/Michael reaction sequence.
The method allows the easy construction of a library of spirooxindoles
in moderate to good yields starting from readily available precursors.
In addition, alkynoic acids are replaced with α,β-unsaturated
acids leading to variably substituted spirooxindoles.