ol5b00355_si_004.cif (544.07 kB)
Expedient Synthesis of Pyrroloquinolinones by Rh-Catalyzed Annulation of N‑Carbamoyl Indolines with Alkynes through a Directed C–H Functionalization/C–N Cleavage Sequence
dataset
posted on 2015-03-20, 00:00 authored by Xiao-Fei Yang, Xu-Hong Hu, Teck-Peng LohA Rh-catalyzed redox-neutral C–H
functionalization of N-carbamoyl indolines with various
internal alkynes has
been developed. The reaction, which involves the sequential cleavage
of the C–H bond of the indoline at the C7-position and the
C–N bond of the urea motif, provides a divergent protocol to
rapidly assemble fused-ring pyrroloquinolinone analogues by
using a direct alkenylation/annulation strategy with high efficiency
and selectivity.