jo0616052_si_001.pdf (1.41 MB)
Expedient Five-Step Synthesis of SIB-1508Y from Natural Nicotine
journal contribution
posted on 2006-10-27, 00:00 authored by Florence F. Wagner, Daniel L. CominsAltinicline (SIB-1508Y), an anti-Parkinson's agent, was
prepared in five steps from natural nicotine in 32% overall
yield via a regioselective substitution of the pyridine ring of
(S)-nicotine.