Eudesmane-Type Sesquiterpenoid
and Guaianolides from Kandelia candel in a Screening
Program for Compounds to
Overcome TRAIL Resistance

Minakawa, Tomohiro; Toume, Kazufumi; Arai, Midori
A.; Sadhu, Samir K.; Ahmed, Firoj; Ishibashi, Masami

doi:10.1021/np300179c.s001

np300179c_si_001.pdf (160.31 kB)

Eudesmane-Type Sesquiterpenoid and Guaianolides from Kandelia candel in a Screening Program for Compounds to Overcome TRAIL Resistance

journal contribution

posted on 2012-08-24, 00:00 authored by Tomohiro Minakawa, Kazufumi Toume, Midori A. Arai, Samir K. Sadhu, Firoj Ahmed, Masami Ishibashi

In a screening program for natural products that can overcome TRAIL resistance, a new eudesmane-type sesquiterpenoid (1), three new guaianolides, mehirugins A–C (2–4), and two known guaianolides (5 and 6) were isolated from a MeOH extract of Kandelia candel leaves. Compounds 1 and 3–6 in combination with TRAIL showed cytotoxic activity in sensitizing TRAIL-resistant human gastric adenocarcinoma cells.