Eudesmane-Type Sesquiterpenoid and Guaianolides from <i>Kandelia candel</i> in a Screening Program for Compounds to Overcome TRAIL Resistance

In a screening program for natural products that can overcome TRAIL resistance, a new eudesmane-type sesquiterpenoid (<b>1</b>), three new guaianolides, mehirugins A–C (<b>2</b>–<b>4</b>), and two known guaianolides (<b>5</b> and <b>6</b>) were isolated from a MeOH extract of <i>Kandelia candel</i> leaves. Compounds <b>1</b> and <b>3</b>–<b>6</b> in combination with TRAIL showed cytotoxic activity in sensitizing TRAIL-resistant human gastric adenocarcinoma cells.