American Chemical Society
Browse
ol990179m_si_001.pdf (279.64 kB)

Enzymatic Selective Dehydration and Skeleton Rearrangement of Paclitaxel Precursors

Download (279.64 kB)
journal contribution
posted on 1999-08-12, 00:00 authored by Donghyun Lee, Mahn-Joo Kim
Enzymatic dehydration reactions to remove selectively the chemically least reactive 13-hydroxyl group of 10-deacetylbaccatin III and its derivatives 2ac are described. The elimination of the 13-OH takes place with skeleton rearrangement, allowing us to synthesize some interesting diterpenoids in good yields.

History