ol990179m_si_001.pdf (279.64 kB)
Enzymatic Selective Dehydration and Skeleton Rearrangement of Paclitaxel Precursors
journal contribution
posted on 1999-08-12, 00:00 authored by Donghyun Lee, Mahn-Joo KimEnzymatic dehydration reactions to remove selectively the chemically least reactive 13-hydroxyl group of 10-deacetylbaccatin III and its derivatives
2a−c are described. The elimination of the 13-OH takes place with skeleton rearrangement, allowing us to synthesize some interesting diterpenoids
in good yields.