Enzymatic Selective Dehydration and Skeleton Rearrangement of Paclitaxel Precursors

1999-08-12T00:00:00Z (GMT) by Donghyun Lee Mahn-Joo Kim
Enzymatic dehydration reactions to remove selectively the chemically least reactive 13-hydroxyl group of 10-deacetylbaccatin III and its derivatives <b>2a</b><b>−</b><b>c</b> are described. The elimination of the 13-OH takes place with skeleton rearrangement, allowing us to synthesize some interesting diterpenoids in good yields.