Environmentally Friendly Protocol for the Oxidative Iodofunctionalization of Olefins in a Green Solvent

An environmentally friendly iodofunctionalization of olefins for the synthesis of various iodinated products was developed via the oxidative umpolung of iodide using I₂O₅ as the inorganic oxidant. The distinct advantages of this protocol over all previous methods include no generation of organic byproducts and the use of a green solvent, thus greatly reducing the environmental impact. Additionally, mild reaction conditions, good yields, and easy-to-operate features make the current reaction system a more attractive method for the synthesis of a variety of medicinal and agrochemical compounds of interest.